Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration

Renae Waters; Settimio Pacelli; Ryan Maloney; Indrani Medhi; Rafeeq P H Ahmed; Arghya Paul

doi:10.1039/c5nr07806g

Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration

Nanoscale. 2016 Apr 14;8(14):7371-6. doi: 10.1039/c5nr07806g.

Authors

Renae Waters¹, Settimio Pacelli¹, Ryan Maloney¹, Indrani Medhi², Rafeeq P H Ahmed³, Arghya Paul¹

Affiliations

¹ BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, KS, USA. arghyapaul@ku.edu.
² SRM University, Kattankulathur 603203, Tamilnadu, India.
³ Department of Pathology, University of Cincinnati, 231-Albert Sabin Way, Cincinnati 45267, OH, USA.

Abstract

A nanocomposite hydrogel with photocrosslinkable micro-porous networks and a nanoclay component was successfully prepared to control the release of growth factor-rich stem cell secretome. The proven pro-angiogenic and cardioprotective potential of this new bioactive system provides a valuable therapeutic platform for cardiac tissue repair and regeneration.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aluminum Silicates / chemistry*
Cell Culture Techniques
Cells, Cultured
Clay
Humans
Hydrogels / chemistry*
Intercellular Signaling Peptides and Proteins / metabolism*
Mesenchymal Stem Cells / cytology
Mesenchymal Stem Cells / metabolism*
Myocardium / cytology
Myocardium / metabolism
Nanostructures / chemistry*
Regenerative Medicine*

Substances

Aluminum Silicates
Hydrogels
Intercellular Signaling Peptides and Proteins
Clay

Abstract

Publication types

MeSH terms

Substances

Grants and funding