Point-of-Need bioanalytics based on planar optical interferometry

E Makarona; P Petrou; S Kakabakos; K Misiakos; I Raptis

doi:10.1016/j.biotechadv.2016.02.005

Point-of-Need bioanalytics based on planar optical interferometry

Biotechnol Adv. 2016 May-Jun;34(3):209-33. doi: 10.1016/j.biotechadv.2016.02.005. Epub 2016 Feb 11.

Authors

E Makarona¹, P Petrou², S Kakabakos², K Misiakos¹, I Raptis³

Affiliations

¹ Optical Biosensors Lab, Institute of Nanoscience and Nanotechnology, NCSR "Demokritos", 15310 Athens, Greece.
² Immunoassay/Immunosensors Lab, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, NCSR "Demokritos", 15310 Athens, Greece.
³ Optical Biosensors Lab, Institute of Nanoscience and Nanotechnology, NCSR "Demokritos", 15310 Athens, Greece. Electronic address: i.raptis@inn.demokritos.gr.

PMID: 26876018
DOI: 10.1016/j.biotechadv.2016.02.005

Abstract

This review brings about a comprehensive presentation of the research on interferometric transducers, which have emerged as extremely promising candidates for viable, truly-marketable solutions for PoN applications due to the attested performance that has reached down to 10(-8) in term of effective refractive index changes. The review explores the operation of the various interferometric architectures along with their design, fabrication, and analytical performance aspects. The issues of biosensor functionalization and immobilization of receptors are also addressed. As a conclusion, the comparison among them is attempted in order to delve into and acknowledge their current limitations, and define the future trends.

Keywords: Biofunctionalization; Biosensor; Interferometry; Label-free detection; Planar waveguide; Point-of-Need.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Equipment Design
Interferometry / instrumentation
Interferometry / methods*
Point-of-Care Systems*
Systems Integration