Molecular surveillance of antimalarial drug resistance related genes in Plasmodium falciparum isolates from Eritrea

Michela Menegon; Abduselam M Nurahmed; Albadawi A Talha; Bakri Y M Nour; Carlo Severini

doi:10.1016/j.actatropica.2016.02.007

Molecular surveillance of antimalarial drug resistance related genes in Plasmodium falciparum isolates from Eritrea

Acta Trop. 2016 May:157:158-61. doi: 10.1016/j.actatropica.2016.02.007. Epub 2016 Feb 11.

Authors

Michela Menegon¹, Abduselam M Nurahmed², Albadawi A Talha³, Bakri Y M Nour⁴, Carlo Severini⁵

Affiliations

¹ Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. Electronic address: michela.menegon@iss.it.
² Faculty of Medical Laboratory Sciences, University of Gezira, P.O. Box 20, Wad Medani, Sudan. Electronic address: peace.abdu@gmail.com.
³ Faculty of Medical Laboratory Sciences, University of Gezira, P.O. Box 20, Wad Medani, Sudan. Electronic address: badawiat@yahoo.com.
⁴ Blue Nile Research National Institute for Communicable Diseases, University of Gezira, P.O. Box 20, Wad Medani, Sudan. Electronic address: bakrinour@gmail.com.
⁵ Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. Electronic address: carlo.severini@iss.it.

PMID: 26875763
DOI: 10.1016/j.actatropica.2016.02.007

Abstract

The introduction of artemisinin-based combination therapy has led to extraordinary results in malaria control, however the recent emergence of partial resistance to artemisinin therapy in Southeast Asia jeopardizes these successes. This study aimed at investigating resistance to the antimalarial drugs by evaluating the polymorphisms in the PfK13, Pfcrt and Pfmdr1 genes in Plasmodium falciparum isolates obtained from patients in Eritrea.

Keywords: Drug resistance; Eritrea; Kelch 13 propeller; Pfcrt; Pfmdr1; Plasmodium falciparum.

MeSH terms

Adolescent
Adult
Aged
Antimalarials / pharmacology*
Artemisinins / pharmacology*
Child
Child, Preschool
Drug Resistance / genetics*
Eritrea / epidemiology
Female
Genes, Protozoan*
Humans
Infant
Malaria, Falciparum / drug therapy*
Malaria, Falciparum / epidemiology
Male
Middle Aged
Plasmodium falciparum / genetics*
Polymorphism, Genetic
Prevalence
Young Adult

Substances

Antimalarials
Artemisinins
artemisinin