Single-strand gap repair involves both RecF and RecBCD pathways

Curr Genet. 2016 Aug;62(3):519-21. doi: 10.1007/s00294-016-0575-5. Epub 2016 Feb 13.

Abstract

Homologous recombination repairs discontinuities in DNA including single-strand gaps (SSGs) and double-strand breaks (DSBs). This commentary describes how the RecBCD and RecF pathways might be exchangeable for the repair of their respective DSB and SSG canonical substrates. In particular, I will discuss how the RecBCD pathway could engage in the repair of an SSG even when the latter is not associated with a DSB.

Keywords: Broken chromosomes; DNA damage; DNA repair; DNA replication; Double-strand break; Homologous recombination; RecA; RecBCD; RecF; Single-strand gap.

Publication types

  • Review

MeSH terms

  • Bacterial Proteins / metabolism*
  • DNA Damage
  • DNA Repair*
  • DNA, Single-Stranded / genetics*
  • DNA, Single-Stranded / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Escherichia coli / genetics
  • Escherichia coli / metabolism
  • Exodeoxyribonuclease V / metabolism*
  • Recombination, Genetic
  • Substrate Specificity

Substances

  • Bacterial Proteins
  • DNA, Single-Stranded
  • DNA-Binding Proteins
  • recF protein, Bacteria
  • Exodeoxyribonuclease V