Acute pancreatitis as a complication of childhood cancer treatment

Cancer Med. 2016 May;5(5):827-36. doi: 10.1002/cam4.649. Epub 2016 Feb 13.

Abstract

Acute pancreatitis (AP) is now well recognized as a possible complication of childhood cancer treatment, interrupting the chemotherapy regimen, and requiring prolonged hospitalization, possibly with intensive care and surgical intervention, thereby compromising the effect of chemotherapy and the remission of the underlying malignant disease. This review summarizes the current literature and presents the various etiological factors for AP during chemotherapy as well as modern trends in the diagnosis and therapy of AP in children.

Keywords: Acute pancreatitis; L-asparaginase; childhood cancer; diagnosis; management.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Disease
  • Antineoplastic Agents / adverse effects*
  • Child
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Humans
  • Neoplasms / therapy*
  • Pancreatitis / chemically induced
  • Pancreatitis / diagnosis
  • Pancreatitis / etiology*
  • Pancreatitis / therapy

Substances

  • Antineoplastic Agents