Seroprevalence of antibodies against GII.4 norovirus among children in Pune, India

J Med Virol. 2016 Sep;88(9):1636-40. doi: 10.1002/jmv.24495. Epub 2016 Feb 24.

Abstract

This study reports the seroprevalence of antibodies against GII.4 norovirus among children (≤5 years) in Pune, India. Of 191 serum specimens, 98 (51.3%) tested positive with 61, 34 and 3 having IgG, IgG-IgA and IgG-IgA-IgM, respectively. Histoblood group antigen (HBGA)-blocking antibodies were detected in 33 of the 54 tested positive specimens. IgG and blocking antibody prevalence and titer varied with age and was lowest among children aged 6-23 months. Antibody-positive children, suggesting past norovirus exposure, showed significantly lower faecal norovirus RNA detection rate than antibody-negative children. Further investigation of the seroepidemiology of norovirus infections in India is warranted. J. Med. Virol. 88:1636-1640, 2016. © 2016 Wiley Periodicals, Inc.

Keywords: HBGA-blocking antibody; IgA; IgG; IgM; protection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Blocking / blood
  • Antibodies, Blocking / immunology
  • Antibodies, Viral / blood*
  • Caliciviridae Infections / epidemiology*
  • Caliciviridae Infections / immunology
  • Child, Preschool
  • Feces / virology*
  • Female
  • Gastroenteritis / immunology
  • Gastroenteritis / virology
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • India / epidemiology
  • Infant
  • Male
  • Norovirus / immunology*
  • RNA, Viral / isolation & purification
  • Seroepidemiologic Studies*

Substances

  • Antibodies, Blocking
  • Antibodies, Viral
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • RNA, Viral