Update on the Use of Botulinum Toxin Therapy for Focal and Task-Specific Dystonias

Semin Neurol. 2016 Feb;36(1):41-6. doi: 10.1055/s-0035-1571211. Epub 2016 Feb 11.

Abstract

Focal dystonia is defined by anatomical distribution and represents a distinct entity from generalized dystonia. Task-specific dystonia occurs in the context of specific patterns of movement. Botulinum neurotoxin (BoNT) injections are the treatment of choice in most cases. Several formulations are available; the approved indications, dosing, and some administration details, differ between them. The major forms of focal and task-specific dystonia are reviewed, along with the evidence for BoNT therapy, the expected benefit and side effects, and practical points guiding the injections.

Publication types

  • Review

MeSH terms

  • Acetylcholine Release Inhibitors / administration & dosage
  • Animals
  • Botulinum Toxins / administration & dosage*
  • Dystonia / diagnosis
  • Dystonia / drug therapy
  • Dystonic Disorders / diagnosis
  • Dystonic Disorders / drug therapy*
  • Humans

Substances

  • Acetylcholine Release Inhibitors
  • Botulinum Toxins

Supplementary concepts

  • Dystonia, Focal, Task-Specific