Abstract
Copeptin is the C-terminal end of pre-provasopressin released equimolar to vasopressin into circulation and recently discussed as promising cardiovascular biomarker amendatory to established markers such as troponins. Vasopressin is a cytokine synthesized in the hypothalamus. A direct release of copeptin from the heart into the circulation is implied by data from a rat model showing a cardiac origin in hearts put under cardiovascular wall stress. Therefore, evaluation of a potential release of copeptin from the human heart in acute myocardial infarction (AMI) has been done.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aorta / metabolism
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Aorta / physiopathology
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Biomarkers / blood
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Cardiac Catheterization
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Cohort Studies
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Coronary Circulation
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Female
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Glycopeptides / blood*
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Glycopeptides / metabolism
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Humans
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Hypertension / blood
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Hypertension / complications
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Hypertension / physiopathology
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Male
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Middle Aged
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Models, Cardiovascular*
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Myocardial Infarction / blood*
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Myocardial Infarction / complications
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Myocardial Infarction / physiopathology
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Myocardium / metabolism
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Myocardium / pathology
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Obesity / blood
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Obesity / complications
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Obesity / physiopathology
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Smoking / blood
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Smoking / physiopathology
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Troponin T / blood*
Substances
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Biomarkers
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Glycopeptides
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Troponin T
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copeptins