5' Adenosine Monophosphate-Activated Protein Kinase Modulators as Anticancer Agents

Abhishek Thakur; Nirnoy Dan; Soumendranath Bhakat; Venkatesan Jayaprakash; Sugato Banerjee

doi:10.2174/1871520616666160211124240

5' Adenosine Monophosphate-Activated Protein Kinase Modulators as Anticancer Agents

Anticancer Agents Med Chem. 2016;16(8):961-972. doi: 10.2174/1871520616666160211124240.

Authors

Abhishek Thakur, Nirnoy Dan, Soumendranath Bhakat, Venkatesan Jayaprakash, Sugato Banerjee¹

Affiliation

¹ Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi: 835215.

PMID: 26863881
DOI: 10.2174/1871520616666160211124240

Abstract

In spite of tremendous advancement in the field of cancer therapy, it is still one of the leading causes of death worldwide. One of the newest targets in the field of cancer therapeutics is 5'Adenosine Mono Phosphate activated protein kinase (AMPK). In vitro and in vivo evidences suggest anti-cancer activity of AMPK. AMPK activation may promote catabolism while preventing the anabolic processes of cell. Thus it may modulate cellular protein and lipid metabolism and affect the growth and division of cell. Here we review the mechanisms of action of AMPK modulators as future anti-cancer agents.

Keywords: AMPK; anti-cancer; diabetes; natural; synthetic.