Assessment of intracranial aneurysm rupture based on morphology parameters and anatomical locations

Yongtao Zheng; Feng Xu; Jinma Ren; Qiang Xu; Yingjun Liu; Yanlong Tian; Bing Leng

doi:10.1136/neurintsurg-2015-012112

Assessment of intracranial aneurysm rupture based on morphology parameters and anatomical locations

J Neurointerv Surg. 2016 Dec;8(12):1240-1246. doi: 10.1136/neurintsurg-2015-012112. Epub 2016 Jan 11.

Authors

Yongtao Zheng¹, Feng Xu¹, Jinma Ren², Qiang Xu³, Yingjun Liu¹, Yanlong Tian¹, Bing Leng¹

Affiliations

¹ Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
² Center for Health Outcomes Research, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA.
³ Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

PMID: 26863105
DOI: 10.1136/neurintsurg-2015-012112

Abstract

Objectives: The aim of the present study was to identify image-based morphological parameters and anatomical locations associated with intracranial aneurysm (IA) rupture.

Methods: Nine morphological parameters and aneurysm location were evaluated in 150 patients with saccular IAs (82 unruptured, 68 ruptured) using three-dimensional geometry. Aneurysm location and morphological parameters including size, aspect ratio, size ratio, height-width ratio, flow angle, aneurysm inclination angle, parent artery angle, vessel angle, and aneurysm shape were explored to identify a correlation with aneurysm rupture. These factors were analyzed using a two-tailed independent Student t test or the χ test for significance. Significant factors were further examined using logistic regression analysis. Additionally, receiver operating characteristic (ROC) analysis was performed to evaluate each parameter.

Results: Statistically significant differences were observed in ruptured and unruptured groups for aspect ratio, size ratio, height-width ratio, flow angle, aneurysm inclination angle, vessel angle, aneurysm shape, and aneurysm location. Logistic regression analysis further revealed that size ratio (OR 1.66; 95% CI 1.05 to 2.64), height-width ratio (OR 14.22; 95% CI 2.67 to 75.88), aneurysm inclination angle (OR 1.04; 95% CI 1.01 to 1.07), aneurysm shape (OR 4.68; 95% CI 2.44 to 8.98), and aneurysm location (OR 1.60; 95% CI 1.15 to 2.23) had the strongest independent correlation with ruptured IA. The ROC analysis showed that the size ratio and flow angle had the highest area under the curve, with values of 0.735 and 0.730, respectively.

Conclusions: Size ratio, height-width ratio, aneurysm inclination angle, aneurysm shape, and aneurysm location might be important for discriminating between ruptured and unruptured aneurysms. Further investigation will determine whether these morphological parameters and anatomical locations will be reliable predictors of aneurysm rupture.

Keywords: Aneurysm.

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