TNFα-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38α MAPK Pathway

Nomeda Girnius; Roger J Davis

doi:10.1016/j.ccell.2016.01.008

TNFα-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38α MAPK Pathway

Cancer Cell. 2016 Feb 8;29(2):131-3. doi: 10.1016/j.ccell.2016.01.008.

Authors

Nomeda Girnius¹, Roger J Davis²

Affiliations

¹ Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
² Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA; Howard Hughes Medical Institute. Electronic address: roger.davis@umassmed.edu.

PMID: 26859448
DOI: 10.1016/j.ccell.2016.01.008

Abstract

Smac mimetics (SMs), a class of drugs that can promote tumor cell death, represent a potential therapeutic strategy for the treatment of cancer. In this issue of Cancer Cell, Lalaoui et al. (2016) report that SM efficacy can be potently increased by inhibition of the p38α MAPK/MK2 signaling pathway.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Antineoplastic Agents / therapeutic use*
Humans
Intracellular Signaling Peptides and Proteins / antagonists & inhibitors*
Intracellular Signaling Peptides and Proteins / physiology*
Leukemia / drug therapy*
Mitochondrial Proteins / physiology*
Molecular Mimicry*
Protein Serine-Threonine Kinases / antagonists & inhibitors*
p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors*

Substances

Antineoplastic Agents
Intracellular Signaling Peptides and Proteins
Mitochondrial Proteins
Protein Serine-Threonine Kinases
p38 Mitogen-Activated Protein Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding