Antimicrobial Resistance in Salmonella in the United States from 1948 to 1995

Daniel A Tadesse; Aparna Singh; Shaohua Zhao; Mary Bartholomew; Niketta Womack; Sherry Ayers; Patricia I Fields; Patrick F McDermott

doi:10.1128/AAC.02536-15

Antimicrobial Resistance in Salmonella in the United States from 1948 to 1995

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2567-71. doi: 10.1128/AAC.02536-15. Print 2016 Apr.

Authors

Daniel A Tadesse¹, Aparna Singh², Shaohua Zhao¹, Mary Bartholomew³, Niketta Womack¹, Sherry Ayers¹, Patricia I Fields⁴, Patrick F McDermott⁵

Affiliations

¹ U.S. Food and Drug Administration, Center for Veterinary Medicine, U.S. Department of Health and Human Services, Laurel, Maryland, USA.
² National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, USA.
³ U.S. Food and Drug Administration, Center for Veterinary Medicine, U.S. Department of Health and Human Services, Rockville, Maryland, USA.
⁴ Centers for Disease Control and Prevention, Division of Foodborne, Waterborne, and Environmental Diseases, U.S. Department of Health and Human Services, Atlanta, Georgia, USA.
⁵ U.S. Food and Drug Administration, Center for Veterinary Medicine, U.S. Department of Health and Human Services, Laurel, Maryland, USA patrick.mcdermott@fda.hhs.gov.

Abstract

We conducted a retrospective study of 2,149 clinicalSalmonellastrains to help document the historical emergence of antimicrobial resistance. There were significant increases in resistance to older drugs, including ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline, which were most common inSalmonella entericaserotype Typhimurium. An increase in multidrug resistance was observed for each decade since the 1950s. These data help show howSalmonellaevolved over the past 6 decades, after the introduction of new antimicrobial agents.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Ampicillin / pharmacology
Anti-Bacterial Agents / pharmacology*
Chloramphenicol / pharmacology
Drug Resistance, Multiple, Bacterial / genetics*
Evolution, Molecular
Humans
Microbial Sensitivity Tests
Phenotype
Public Health Surveillance
Salmonella Infections / drug therapy
Salmonella Infections / epidemiology*
Salmonella Infections / microbiology
Salmonella typhimurium / classification
Salmonella typhimurium / drug effects
Salmonella typhimurium / genetics*
Salmonella typhimurium / growth & development
Serogroup
Streptomycin / pharmacology
Sulfamethoxazole / pharmacology
Tetracycline / pharmacology
United States / epidemiology

Substances

Anti-Bacterial Agents
Chloramphenicol
Ampicillin
Tetracycline
Sulfamethoxazole
Streptomycin