Combinatorial synthesis of deuterium-enriched (S)-oxybutynin

Feng Li; Wenfeng Jiang; Anthony W Czarnik; Wenbao Li

doi:10.1007/s11030-016-9660-4

Combinatorial synthesis of deuterium-enriched (S)-oxybutynin

Mol Divers. 2016 Aug;20(3):605-10. doi: 10.1007/s11030-016-9660-4. Epub 2016 Feb 6.

Authors

Feng Li^{1

2}, Wenfeng Jiang^{1

2}, Anthony W Czarnik³, Wenbao Li^{4

5}

Affiliations

¹ School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.
² Marine Biomedical Research Institute of Qingdao, Qingdao, 266073, People's Republic of China.
³ Department of Chemistry, University of Nevada, Reno, Reno, 89557-0216, USA. aczarnik@unr.edu.
⁴ School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China. wbli92128@ouc.edu.cn.
⁵ Marine Biomedical Research Institute of Qingdao, Qingdao, 266073, People's Republic of China. wbli92128@ouc.edu.cn.

PMID: 26852022
DOI: 10.1007/s11030-016-9660-4

Abstract

The concept of deuterium enrichment has gained more attention due to its advantages in the studies of clinical pharmacokinetics and metabolic profiles. In addition, it is cost and time efficient to develop deuterium-enriched drugs. Herein we built a combinatorial library of deuterated (S)-oxybutynins which all 8 D-compounds were characterized by MS, [Formula: see text] NMR and [Formula: see text]C NMR.

Keywords: Combinatorial chemistry; Derivatives; Deuterium; Oxybutynin.

MeSH terms

Combinatorial Chemistry Techniques
Deuterium / chemistry*
Mandelic Acids / chemical synthesis*
Mandelic Acids / chemistry
Molecular Structure

Substances

Mandelic Acids
Deuterium
oxybutynin