Strategies in functional proteomics: Unveiling the pathways to precision oncology

Cancer Lett. 2016 Nov 1;382(1):86-94. doi: 10.1016/j.canlet.2016.01.049. Epub 2016 Feb 2.

Abstract

Personalised strategies in cancer care are required to overcome the therapeutic challenges posed by variability between patients and disease subsets. To this end, enhanced precision tools must be developed to describe the molecular drivers of malignant proliferation. Such tools must also identify druggable targets and biomarkers in order to provide essential information regarding drug development and therapeutic outcome. Here we discuss how proteomics-based approaches provide a set of viable methodologies capable of delivering quantitative information throughout the main stages of personalised oncology and a ratiometric platform that delivers systems-wide methods for drug evaluation.

Keywords: Biomarkers; Cancer drivers; Drug development; Personalised oncology; Proteomics; Therapeutics.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use*
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism*
  • Computational Biology
  • Databases, Protein
  • Drug Discovery / methods*
  • Humans
  • Molecular Diagnostic Techniques
  • Molecular Targeted Therapy
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Patient Selection
  • Precision Medicine / methods*
  • Predictive Value of Tests
  • Protein Interaction Maps
  • Proteomics / methods*
  • Signal Transduction / drug effects

Substances

  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Neoplasm Proteins