Abstract
Objective:
Recently, it has been shown that exposure to welding fumes containing both zinc and copper leads to asymptomatic systemic inflammation in humans as shown by an increase of blood C-reactive protein. In the present study, it was investigated which metal is responsible for this effect.
Methods:
Fifteen healthy male subjects were exposed under controlled conditions to welding fumes containing either zinc, or copper, or copper and zinc.
Results:
For each exposure blood C-reactive protein increased.
Conclusions:
Copper- and zinc-containing welding fumes are able to induce systemic inflammation.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Air Pollutants, Occupational / toxicity*
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Asymptomatic Diseases
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Biomarkers / blood
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C-Reactive Protein / metabolism
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Copper / toxicity*
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Cross-Over Studies
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Healthy Volunteers
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Humans
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Inflammation / blood
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Inflammation / chemically induced*
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Inflammation / diagnosis
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Male
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Occupational Diseases / blood
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Occupational Diseases / chemically induced*
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Occupational Diseases / diagnosis
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Occupational Exposure / adverse effects
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Welding*
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Zinc / toxicity*
Substances
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Air Pollutants, Occupational
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Biomarkers
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Copper
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C-Reactive Protein
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Zinc