Chronic rhinosinusitis (CRS) is an epidemiologically important, chronic inflammatory disease process affecting the paranasal sinuses with significant and extensively reported economic implications. Despite an elusive pathophysiologic mechanism underlying this disease process, treatment outcomes are encouraging with the employment of an array of medical and surgical therapies. The goal of this paper is to provide a comprehensive, up to date analysis of the literature concerning the medical management of CRS by highlighting the most recent evidence based recommendations addressing this ongoing field of research.
Keywords: Chronic rhinosinusitis; anti-IL 5; anti-IgE; antimicrobial therapy; aspirin desensitization; immunotherapy; intranasal corticosteroids; leukotriene antagonists; oral corticosteroids; topical irrigations.