Framework Cationization by Preemptive Coordination of Open Metal Sites for Anion-Exchange Encapsulation of Nucleotides and Coenzymes

Xiang Zhao; Chengyu Mao; Karen Tu Luong; Qipu Lin; Quan-Guo Zhai; Pingyun Feng; Xianhui Bu

doi:10.1002/anie.201510812

Framework Cationization by Preemptive Coordination of Open Metal Sites for Anion-Exchange Encapsulation of Nucleotides and Coenzymes

Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2768-72. doi: 10.1002/anie.201510812. Epub 2016 Feb 5.

Authors

Xiang Zhao¹, Chengyu Mao², Karen Tu Luong¹, Qipu Lin³, Quan-Guo Zhai³, Pingyun Feng^{3

2}, Xianhui Bu⁴

Affiliations

¹ Department of Chemistry and Biochemistry, California State University, Long Beach, 1250 Bellflower Boulevard, Long Beach, CA, 90840, USA.
² Materials Science and Engineering Program, University of California, Riverside, CA, 92521, USA.
³ Department of Chemistry, University of California, Riverside, CA, 92521, USA.
⁴ Department of Chemistry and Biochemistry, California State University, Long Beach, 1250 Bellflower Boulevard, Long Beach, CA, 90840, USA. xianhui.bu@csulb.edu.

PMID: 26847038
DOI: 10.1002/anie.201510812

Abstract

Cationic frameworks can selectively trap anions through ion exchange, and have applications in ion chromatography and drug delivery. However, cationic frameworks are much rarer than anionic or neutral ones. Herein, we propose a concept, preemptive coordination (PC), for targeting positively charged metal-organic frameworks (P-MOFs). PC refers to proactive blocking of metal coordination sites to preclude their occupation by neutralizing ligands such as OH(-) . We use 20 MOFs to show that this PC concept is an effective approach for developing P-MOFs whose high stability, porosity, and anion-exchange capability allow immobilization of anionic nucleotides and coenzymes, in addition to charge- and size-selective capture or separation of organic dyes. The CO2 and C2 H2 uptake capacity of 117.9 cm(3) g(-1) and 148.5 cm(3) g(-1) , respectively, at 273 K and 1 atm, is exceptionally high among cationic framework materials.

Keywords: anion separation; cationic frameworks; ion exchange; metal-organic frameworks.

Publication types

Research Support, Non-U.S. Gov't