pH-Responsive Fe(III)-Gallic Acid Nanoparticles for In Vivo Photoacoustic-Imaging-Guided Photothermal Therapy

Jianfeng Zeng; Ming Cheng; Yong Wang; Ling Wen; Ling Chen; Zhen Li; Yongyou Wu; Mingyuan Gao; Zhifang Chai

doi:10.1002/adhm.201500898

pH-Responsive Fe(III)-Gallic Acid Nanoparticles for In Vivo Photoacoustic-Imaging-Guided Photothermal Therapy

Adv Healthc Mater. 2016 Apr 6;5(7):772-80. doi: 10.1002/adhm.201500898. Epub 2016 Feb 4.

Authors

Jianfeng Zeng^{1

2}, Ming Cheng³, Yong Wang^{1

2}, Ling Wen^{1

2}, Ling Chen^{1

2}, Zhen Li^{1

2

4}, Yongyou Wu³, Mingyuan Gao⁵, Zhifang Chai^{1

2}

Affiliations

¹ Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, 215123, China.
² Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, China.
³ The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
⁴ Institute for Superconducting & Electronic Materials, The University of Wollongong, NSW, 2500, Australia.
⁵ Institute of Chemistry, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences (BNLMS), Beijing, 100190, China.

PMID: 26845393
DOI: 10.1002/adhm.201500898

Abstract

pH-responsive biocompatible Fe(III)-gallic acid nanoparticles with strong near-infrared absorbance are very stable in mild acidic conditions, but easily decomposed in neutral conditions, which enables the nanoparticles to be stable in a tumor and easily metabolized in other organs, thus providing a safe nanoplatform for in vivo photoacoustic imaging/photothermal therapy theranostic applications.

Keywords: metal complex nanoparticles; pH-sensitive nanoparticles; photoacoustic imaging; photothermal therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Cell Survival
Diagnostic Imaging*
Gallic Acid / chemistry*
Humans
Hydrogen-Ion Concentration
Hyperthermia, Induced*
Iron / chemistry*
Mice, Inbred BALB C
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Photoacoustic Techniques / methods*
Phototherapy*
Tissue Distribution

Substances

Gallic Acid
Iron