Inflammatory pseudotumor (IPT) of the spleen is an extremely rare benign lesion. We herein report an additional case of a 64-year-old man with IPT of spleen to compare with seven cases previously reported in the literature. However, the immunohistochemical studies has demonstrated to polyclonality of plasma cells which was comparable to these seven previously reported cases. The clinical and pathological findings, as well as the possibilities of etiology and pathogenesis are also described.