A Sustainable Approach to the Stereoselective Synthesis of Diazaheptacyclic Cage Systems Based on a Multicomponent Strategy in an Ionic Liquid

Molecules. 2016 Jan 29;21(2):165. doi: 10.3390/molecules21020165.

Abstract

The microwave-assisted three-component reactions of 3,5-bis(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones, acenaphthenequinone and cyclic α-amino acids in an ionic liquid, 1-butyl-3-methylimidazolium bromide, occurred through a domino sequence affording structurally intriguing diazaheptacyclic cage-like compounds in excellent yields.

Keywords: diazaheptacyclic cage compounds; ionic liquid; microwave-assisted synthesis; multicomponent reactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acenaphthenes / chemistry
  • Acids, Heterocyclic / chemical synthesis*
  • Acids, Heterocyclic / chemistry
  • Catalysis
  • Imidazoles / chemistry
  • Ionic Liquids / chemistry*
  • Microwaves
  • Molecular Structure
  • Pyridones / chemistry

Substances

  • Acenaphthenes
  • Acids, Heterocyclic
  • Imidazoles
  • Ionic Liquids
  • Pyridones
  • acenaphthenequinone
  • 1-butyl-3-methylimidazolium chloride