Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Poomy Pandey; Bailee Sliker; Haley L Peters; Amit Tuli; Jonathan Herskovitz; Kaitlin Smits; Abhilasha Purohit; Rakesh K Singh; Jixin Dong; Surinder K Batra; Donald W Coulter; Joyce C Solheim

doi:10.18632/oncotarget.7103

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Oncotarget. 2016 Apr 12;7(15):19430-44. doi: 10.18632/oncotarget.7103.

Authors

Poomy Pandey¹, Bailee Sliker¹, Haley L Peters^{1

2}, Amit Tuli^{1

3

4}, Jonathan Herskovitz¹, Kaitlin Smits¹, Abhilasha Purohit⁵, Rakesh K Singh^{5

6}, Jixin Dong^{1

6}, Surinder K Batra^{3

6}, Donald W Coulter^{6

7}, Joyce C Solheim^{1

3

5

6}

Affiliations

¹ Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
² Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³ Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
⁴ Wellcome Trust/DBT India Alliance Intermediate Fellow, CSIR-Institute of Microbial Technology, Chandigarh, India.
⁵ Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
⁶ Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
⁷ Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA.

Abstract

Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members' roles in cancer progression and metastasis.

Keywords: amyloid precursor protein; amyloid precursor-like protein 2; cancer; growth; migration.

Publication types

Review

MeSH terms

Alternative Splicing
Amino Acid Sequence
Amyloid beta-Protein Precursor / chemistry
Amyloid beta-Protein Precursor / genetics
Amyloid beta-Protein Precursor / metabolism*
Animals
Cell Movement*
Cell Proliferation*
Humans
Neoplasms / genetics
Neoplasms / metabolism*
Neoplasms / pathology
Nerve Tissue Proteins / chemistry
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / metabolism*
Protein Unfolding

Substances

APLP2 protein, human
Amyloid beta-Protein Precursor
Nerve Tissue Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding