Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety

Sci Pharm. 2015 Feb 24;83(2):221-31. doi: 10.3797/scipharm.1411-14. Print 2015 Apr-Jun.

Abstract

Thiosulfonate derivatives based on quinones were synthesized for studying "structure-activity relationship" compounds with an acylated and a free amino-group. Anti-platelet activity of the synthesized compounds was determined and the influence of substituents on the activity of the derivatives was assessed.

Keywords: Anti-platelet activity; Quinone; Thiosulfonate.