A switchable DNA origami nanochannel for regulating molecular transport at the nanometer scale

Dianming Wang; Yiyang Zhang; Miao Wang; Yuanchen Dong; Chao Zhou; Mark Antonin Isbell; Zhongqiang Yang; Huajie Liu; Dongsheng Liu

doi:10.1039/c5nr08206d

A switchable DNA origami nanochannel for regulating molecular transport at the nanometer scale

Nanoscale. 2016 Feb 21;8(7):3944-8. doi: 10.1039/c5nr08206d.

Authors

Dianming Wang¹, Yiyang Zhang¹, Miao Wang¹, Yuanchen Dong¹, Chao Zhou¹, Mark Antonin Isbell¹, Zhongqiang Yang¹, Huajie Liu², Dongsheng Liu¹

Affiliations

¹ Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. liudongsheng@tsinghua.edu.
² Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.

PMID: 26839050
DOI: 10.1039/c5nr08206d

Abstract

A nanochannel with a shutter at one end was built by DNA nanotechnology. Using DNA hybridization the shutter could be opened or closed, influencing the transport of materials through the channel. This process was visualized by an enzyme cascade reaction occurring in the structure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / chemistry
Biocompatible Materials / metabolism
DNA / chemistry*
Glucose Oxidase / metabolism
Horseradish Peroxidase / metabolism
Microscopy, Atomic Force
Nanostructures / chemistry*
Nucleic Acid Conformation
Nucleic Acid Hybridization

Substances

Biocompatible Materials
DNA
Glucose Oxidase
Horseradish Peroxidase