Pharmacokinetic and Dynamic of Furosemide in Peritoneal Dialysis Patients

Perit Dial Int. 2016 Jan-Feb;36(1):107-8. doi: 10.3747/pdi.2014.00328.

Abstract

The aim of our study was to evaluate the efficacy and bioavailibility of a commonly used oral furosemide dose (500 mg) compared to a 250 mg intravenous (IV) dose in PD patients with significant residual renal function (urine volume > 100 mL). We also evaluated the immediate blood pressure effect in these patients. The data were obtained from a study we performed for the homologation of a 500-mg dose of furosemide by Health Canada.

Keywords: Furosemide; blood pressure; diuresis; natriuresis; pharmacodynamic; pharmacokinetic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diuretics / pharmacokinetics*
  • Female
  • Furosemide / pharmacokinetics*
  • Humans
  • Male
  • Middle Aged
  • Peritoneal Dialysis*

Substances

  • Diuretics
  • Furosemide