Carbonated hydrocalumite synthesized by the microwave method as a possible antacid

Mater Sci Eng C Mater Biol Appl. 2016 Apr 1:61:875-8. doi: 10.1016/j.msec.2016.01.007. Epub 2016 Jan 6.

Abstract

A carbonated hydrocalumite was synthesized by the microwave method for being used as antacid. The gel was formed using Ca and Al nitrate solutions in a basic medium (NaOH+Na2CO3), then, this gel was aged and heated in a domestic microwave for 2.5 min (1250 W). The obtained white solid was washed with distilled water, dried in an oven at 100 °C for 18 h and characterized by different techniques such as: X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR), BET surface area measurements, scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). Finally, the carbonated hydrocalumite was tested as antacid by using a synthetic gastric juice and its activity was compared with a commercial antacid formulated with hydrotalcite. Results showed that the carbonated hydrocalumite was more effective than that commercial antacid.

Keywords: Antacid; Carbonate calcium; Carbonated hydrocalumite; Microwave method.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aluminum Compounds / chemistry
  • Antacids / chemical synthesis*
  • Antacids / chemistry
  • Calcium Compounds / chemistry
  • Carbonates / chemistry
  • Gels / chemical synthesis
  • Gels / chemistry
  • Microscopy, Electron, Scanning
  • Microwaves*
  • Nitrates / chemistry
  • Spectrometry, X-Ray Emission
  • Spectroscopy, Fourier Transform Infrared
  • X-Ray Diffraction

Substances

  • Aluminum Compounds
  • Antacids
  • Calcium Compounds
  • Carbonates
  • Gels
  • Nitrates
  • aluminum nitrate
  • calcium nitrate