Biocompatibility of new Ti-Nb-Ta base alloys

Mater Sci Eng C Mater Biol Appl. 2016 Apr 1:61:574-8. doi: 10.1016/j.msec.2015.12.071. Epub 2015 Dec 30.

Abstract

β-type titanium alloys are promising materials in the field of medical implants. The effect of β-phase stability on the mechanical properties, corrosion resistance and cytotoxicity of a newly designed β-type (Ti77Nb17Ta6) biocompatible alloys are studied. The β-phase stability was controlled by the addition of small quantities of Fe and O. X-ray diffraction and microstructural analysis showed that the addition of O and Fe stabilized the β-phase in the treated solution condition. The strength and hardness have increased with the increase in β-phase stability while ductility and Young's modulus have decreased. The potentio-dynamic polarization tests showed that the corrosion resistance of the new alloys is better than Ti-6Al-4V alloy by at least ten times. Neutral red uptake assay cytotoxicity test showed cell viability of at least 95%. The new alloys are promising candidates for biomedical applications due to their high mechanical properties, corrosion resistance, and reduced cytotoxicity.

Keywords: Biocompatibility; Corrosion; Cytotoxicity; Titanium alloys; β-phase stability.

MeSH terms

  • Alloys* / chemistry
  • Alloys* / pharmacology
  • Hardness
  • HeLa Cells
  • Humans
  • Materials Testing*
  • Niobium* / chemistry
  • Niobium* / pharmacology
  • Tantalum* / chemistry
  • Tantalum* / pharmacology
  • Titanium* / chemistry
  • Titanium* / pharmacology

Substances

  • Alloys
  • Niobium
  • Tantalum
  • Titanium