Myxoid Neoplasms

Muhammad I Zulfiqar; Umer N Sheikh; Elizabeth A Montgomery

doi:10.1016/j.path.2011.08.012

Myxoid Neoplasms

Surg Pathol Clin. 2011 Sep;4(3):843-64. doi: 10.1016/j.path.2011.08.012.

Authors

Muhammad I Zulfiqar¹, Umer N Sheikh¹, Elizabeth A Montgomery²

Affiliations

¹ Department of Pathology, St John Hospital and Medical Center, 22101 Moross Road, CCB-SB, Detroit, MI 48236, USA.
² Department of Pathology, The Johns Hopkins Medical Institutions, 401 North Broadway, Weinberg 2242, Baltimore, MD 21231-2410, USA.

PMID: 26837651
DOI: 10.1016/j.path.2011.08.012

Abstract

Myxoid tumors of soft tissue constitute a heterogeneous group of neoplasms characterized by the presence of a myxoid stromal matrix, which appears on H&E as an amorphous material and may be confused with edema. Superficial myxoid lesions in general are benign and deep ones are malignant. Grossly, they have a variable gelatinous quality and overlapping histologic features that may present diagnostic difficulties for pathologists. Most are sporadic neoplasms, with only a small percentage arising in patients with hereditary disorders. Discussed are key features of classic myxoid lesions, histologic features, characteristic clinical presentations, immunohistochemical patterns, cytogenetic analysis, and differential diagnosis.