One-Shot Immunomodulatory Nanodiamond Agents for Cancer Immunotherapy

Yu Zhang; Zhifen Cui; Huating Kong; Kai Xia; Liang Pan; Jiang Li; Yanhong Sun; Jiye Shi; Lihua Wang; Ying Zhu; Chunhai Fan

doi:10.1002/adma.201506232

One-Shot Immunomodulatory Nanodiamond Agents for Cancer Immunotherapy

Adv Mater. 2016 Apr 13;28(14):2699-708. doi: 10.1002/adma.201506232. Epub 2016 Feb 2.

Authors

Yu Zhang¹, Zhifen Cui¹, Huating Kong¹, Kai Xia¹, Liang Pan¹, Jiang Li¹, Yanhong Sun¹, Jiye Shi^{2

3}, Lihua Wang¹, Ying Zhu¹, Chunhai Fan^{1

4}

Affiliations

¹ Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
² Kellogg College, University of Oxford, Banbury Road, Oxford, OX2 6PN, UK.
³ UCB Pharma, 208 Bath Road, Slough, SL1 3WE, UK.
⁴ School of Life Science and Technology, ShanghaiTech University, Shanghai, 201200, China.

PMID: 26833992
DOI: 10.1002/adma.201506232

Abstract

The use of functional nanodiamonds (fNDs) to deliver CpG oligonucleotides (ODNs) for sustained immunostimulation is reported. It is demonstrated that monotherapy using this immunostimulatory agent significantly suppresses the tumor growth in two murine tumor models. This fND-based nanoagent opens new opportunities for immunotherapy, as well as clinical applications of various types of therapeutic nucleic acids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Cytokines / metabolism
Disease Models, Animal
Drug Carriers / chemistry
Female
Humans
Immunotherapy
Mice
Mice, Inbred ICR
Mice, Nude
Microscopy, Confocal
Nanodiamonds / chemistry*
Neoplasms / therapy*
Oligonucleotides / administration & dosage
Oligonucleotides / chemistry
RAW 264.7 Cells
Transplantation, Heterologous

Substances

Cytokines
Drug Carriers
Nanodiamonds
Oligonucleotides