Nucleotides are required in order to replicate DNA in the developing germline. Here, Chi and colleagues (pp. 307-320) have used Caernohabditis elegans to identify a GLP-1-dependent checkpoint that senses food (bacterially)-supplied nucleotide levels, arresting reproductive development in the absence of sufficient nucleotide supplies.
Keywords: CRP; HT115; cytR; gld-1; nucleotide salvage pathway; nutrient sensing.
© 2016 Shi and Murphy; Published by Cold Spring Harbor Laboratory Press.