Abstract
As angiogenesis is critical for tumor growth and metastasis, potent and selective anti-angiogenic agents with novel modes of action are highly needed for anti-cancer drug discovery. In this review, our studies focusing on the search for anti-angiogenic substances from natural sources, such as bastadins, globostellatic acid X methyl esters and cortistatins from marine sponges, and pyripyropenes from marine-derived fungus, together with senegasaponins from medicinal plant, are summarized.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Angiogenesis Inhibitors / chemistry
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Angiogenesis Inhibitors / isolation & purification*
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Biological Products / chemistry
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Biological Products / isolation & purification*
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Biological Products / pharmacology*
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Humans
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Neoplasms / blood supply
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Neoplasms / drug therapy*
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Neovascularization, Pathologic / drug therapy*
Substances
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Angiogenesis Inhibitors
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Antineoplastic Agents, Phytogenic
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Biological Products