Naphthalenones and Depsidones from a Sponge-Derived Strain of the Fungus Corynespora cassiicola

Molecules. 2016 Jan 28;21(2):160. doi: 10.3390/molecules21020160.

Abstract

Two new naphthalenones, corynenones A and B (1 and 2), and one new depsidone, corynesidone E (3), together with one known depsidone, corynesidone A (4) and two known diphenyl ethers, corynethers A (5) and B (6), were isolated from the sponge-derived fungus Corynespora cassiicola XS-20090I7. Their structures including absolute configurations were determined by spectroscopic data and electronic circular dichroism (ECD) spectra. Compounds 4 and 5 showed cytotoxicity against human promyelocytic leukemia HL-60 and human cervical carcinoma HeLa cell lines.

Keywords: Corynespora cassiicola; cytotoxicity; depsidone; naphthalenone; sponge-derived fungus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Circular Dichroism
  • Depsides / chemistry
  • Depsides / isolation & purification*
  • Depsides / pharmacology
  • HL-60 Cells
  • HeLa Cells
  • Humans
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Molecular Structure
  • Naphthalenes / chemistry
  • Naphthalenes / isolation & purification*
  • Naphthalenes / pharmacology
  • Porifera / microbiology*
  • Saccharomycetales / chemistry*

Substances

  • Depsides
  • Lactones
  • Naphthalenes
  • depsidone