Relationship of long noncoding RNA and viruses

Yao-zhong Ding; Zhong-wang Zhang; Ya-li Liu; Chong-xu Shi; Jie Zhang; Yong-guang Zhang

doi:10.1016/j.ygeno.2016.01.007

Relationship of long noncoding RNA and viruses

Genomics. 2016 Apr;107(4):150-4. doi: 10.1016/j.ygeno.2016.01.007. Epub 2016 Jan 28.

Authors

Yao-zhong Ding¹, Zhong-wang Zhang¹, Ya-li Liu¹, Chong-xu Shi¹, Jie Zhang², Yong-guang Zhang³

Affiliations

¹ State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, China.
² State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, China. Electronic address: zhangjie03@caas.cn.
³ State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, China. Electronic address: zhangyongguang@caas.cn.

PMID: 26826341
DOI: 10.1016/j.ygeno.2016.01.007

Abstract

Long noncoding (lnc)RNAs comprise a diverse group of transcripts including large intervening noncoding (linc)RNAs, natural antisense transcripts (NATs) and intronic lncRNAs. The functions and mechanisms of more than 200 lncRNAs have been studied in vitro and the results suggest that lncRNAs may be molecular markers of prognosis in cancer patients. Some lncRNAs can promote virus replication and allow escape from cytosolic surveillance to suppress antiviral immunity. For example, lncRNA can cause persistent infection by Theiler's virus, and microRNA (miR)-27a/b is important for efficient murine cytomegalovirus (MCMV) replication. The available evidence suggests that lncRNAs may be potential targets of novel antiviral drugs.

Keywords: Adenovirus; Cytomegalovirus; Epstein–Barr virus; Long noncoding RNA; Theiler's virus.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adenoviruses, Human / physiology
Animals
Humans
Introns
Mice
Muromegalovirus / physiology
RNA, Long Noncoding / genetics*
Theilovirus / physiology
Virus Replication*
Viruses*

Substances

RNA, Long Noncoding