Gap junctions play a critical role in electrical synchronization and exchange of small molecules between neighboring cells; connexins are a family of structurally related transmembrane proteins that assemble to form vertebrate gap junctions. Hyperglycemia changes the structure gap junction proteins and their expression, resulting in obstruction of neural regeneration, vascular function and wound healing, and also promoting vascular atherosclerosis. These pathogenic factors would cause diabetic foot ulcers. This article reviews the involvement of connexins in pathogenesis of diabetic foot.
缝隙连接参与了细胞间电信号传递的电偶联和物质交换的代谢偶联, 长期高血糖导致患者缝隙连接蛋白结构及表达发生改变, 机体神经再生、血管生理功能及伤口愈合发生障碍, 同时促进血管动脉粥样硬化形成。这些病变是糖尿病患者足部发生溃疡或坏疽的重要原因。本文就缝隙连接在糖尿病足发生发展中的研究进展进行文献综述。