Copper(i) chloride promoted Csp(2)-N cross-coupling of 1,2-di(pyrimidin-2-yl) disulfides with amines: an efficient approach to obtain C2-amino functionalized pyrimidines

Kai-Jie Wei; Zheng-jun Quan; Zhang Zhang; Yu-xia Da; Xi-cun Wang

doi:10.1039/c5ob02535d

Copper(i) chloride promoted Csp(2)-N cross-coupling of 1,2-di(pyrimidin-2-yl) disulfides with amines: an efficient approach to obtain C2-amino functionalized pyrimidines

Org Biomol Chem. 2016 Feb 28;14(8):2395-8. doi: 10.1039/c5ob02535d.

Authors

Kai-Jie Wei¹, Zheng-jun Quan¹, Zhang Zhang¹, Yu-xia Da¹, Xi-cun Wang¹

Affiliation

¹ Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education, China, Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, P. R. China. quanzhengjun@hotmail.com wangxicun@nwnu.edu.cn and College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, P. R. China.

PMID: 26821885
DOI: 10.1039/c5ob02535d

Abstract

The copper(i)-promoted cross-coupling of 1,2-di(pyrimidin-2-yl) disulfides with aromatic amines and aliphatic amines to deliver C-N coupling products in moderate to good yields is reported in this paper. Central to this strategy is the conversion of disulfides into aryl- and alkyl amines by a copper-promoted chemoselective C-S bond cleavage.

Publication types

Research Support, Non-U.S. Gov't