The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection

Yuanzhi Wang; Zhen Wang; Xin Chen; Hui Zhang; Fei Guo; Ke Zhang; Hanping Feng; Wenyi Gu; Changxin Wu; Lei Ma; Tiansen Li; Chuangfu Chen; Shan Gao

doi:10.3390/genes7020007

The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection

Genes (Basel). 2016 Jan 26;7(2):7. doi: 10.3390/genes7020007.

Authors

Yuanzhi Wang^{1

2}, Zhen Wang³, Xin Chen⁴, Hui Zhang⁵, Fei Guo^{6

7}, Ke Zhang⁸, Hanping Feng⁹, Wenyi Gu¹⁰, Changxin Wu¹¹, Lei Ma¹², Tiansen Li¹³, Chuangfu Chen¹⁴, Shan Gao¹⁵

Affiliations

¹ College of Medicine, Shihezi University, Xinjiang 832000, China. a201511281@126.com.
² Co-Innovation Center for Zoonotic Infectious Diseases in the western region, Shihezi University, Xinjiang 832000, China. a201511281@126.com.
³ College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. b201511281@126.com.
⁴ College of Life Sciences, Nankai University, Tianjin 300071, China. c201511281@126.com.
⁵ College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. zhanghui@shzu.edu.cn.
⁶ College of Medicine, Shihezi University, Xinjiang 832000, China. d201511281@126.com.
⁷ Co-Innovation Center for Zoonotic Infectious Diseases in the western region, Shihezi University, Xinjiang 832000, China. d201511281@126.com.
⁸ College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. e201511281@126.com.
⁹ College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. f201511281@126.com.
¹⁰ College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. g201511281@126.com.
¹¹ College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. h201511281@126.com.
¹² College of Life Sciences, Shihezi University, Xinjiang 832000, China. i201511281@126.com.
¹³ College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. j201511281@126.com.
¹⁴ College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. chenchuangfu@shzu.edu.cn.
¹⁵ College of Life Sciences, Nankai University, Tianjin 300071, China. gao_shan@mail.nankai.edu.cn.

Abstract

Brucella species are the most important zoonotic pathogens worldwide and cause considerable harm to humans and animals. In this study, we presented the complete genome of B. suis 019 isolated from sheep (ovine) with epididymitis. B. suis 019 has a rough phenotype and can infect sheep, rhesus monkeys and possibly humans. The comparative genome analysis demonstrated that B. suis 019 is closest to the vaccine strain B. suis bv. 1 str. S2. Further analysis associated the rsh gene to the pathogenicity of B. suis 019, and the WbkA gene to the rough phenotype of B. suis 019. The 019 complete genome data was deposited in the GenBank database with ID PRJNA308608.

Keywords: B. suis 019; Brucella; comparative genomics; complete genome; cross species.