Abstract
A systematic review investigating the role of Xpert MTB/RIF in the diagnosis of tuberculous pleural effusion (TPE) was conducted. The pooled sensitivities and specificities of Xpert MTB/RIF were 51.4% and 98.6%, respectively, with culture used as a reference standard and 22.7% and 99.8%, respectively, with a composite reference standard (CRS) used as the benchmark. Xpert MTB/RIF has low sensitivity but excellent specificity in the diagnosis of TPE.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.
Publication types
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Evaluation Study
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Meta-Analysis
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Review
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Systematic Review
MeSH terms
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Antitubercular Agents / pharmacology*
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Drug Resistance, Bacterial*
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Humans
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Molecular Diagnostic Techniques / methods*
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / isolation & purification*
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Pleural Effusion / microbiology*
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Rifampin / pharmacology*
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Sensitivity and Specificity
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Tuberculosis, Multidrug-Resistant / diagnosis
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Tuberculosis, Pleural / diagnosis*
Substances
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Antitubercular Agents
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Rifampin
Grants and funding
This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.