RNA binding proteins implicated in Xist-mediated chromosome silencing

Benoit Moindrot; Neil Brockdorff

doi:10.1016/j.semcdb.2016.01.029

RNA binding proteins implicated in Xist-mediated chromosome silencing

Semin Cell Dev Biol. 2016 Aug:56:58-70. doi: 10.1016/j.semcdb.2016.01.029. Epub 2016 Jan 24.

Authors

Benoit Moindrot¹, Neil Brockdorff²

Affiliations

¹ Dept. of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
² Dept. of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address: neil.brockdorff@bioch.ox.ac.uk.

PMID: 26816113
DOI: 10.1016/j.semcdb.2016.01.029

Abstract

Chromosome silencing by Xist RNA occurs in two steps; localisation in cis within the nuclear matrix to form a domain that corresponds to the territory of the inactive X chromosome elect, and transduction of silencing signals from Xist RNA to the underlying chromatin. Key factors that mediate these processes have been identified in a series of recent studies that harnessed comprehensive proteomic or genetic screening strategies. In this review we discuss these findings in light of prior knowledge both of Xist-mediated silencing and known functions/properties of the novel factors.

Keywords: Chromatin; Epigenetic; Non-coding RNA; X chromosome inactivation; Xist.

Publication types

Review

MeSH terms

Animals
Heterogeneous-Nuclear Ribonucleoproteins / metabolism
Humans
Models, Genetic
RNA, Long Noncoding / metabolism*
RNA-Binding Proteins / metabolism*
X Chromosome Inactivation / genetics*

Substances

Heterogeneous-Nuclear Ribonucleoproteins
RNA, Long Noncoding
RNA-Binding Proteins
XIST non-coding RNA