Formosins A-F: Diterpenoids with Anti-microbial Activities from Excoecaria formosana

Bing-Dong Lin; Bin Zhou; Lei Dong; Yan Wu; Jian-Min Yue

doi:10.1007/s13659-016-0086-6

Formosins A-F: Diterpenoids with Anti-microbial Activities from Excoecaria formosana

Nat Prod Bioprospect. 2016 Feb;6(1):57-61. doi: 10.1007/s13659-016-0086-6. Epub 2016 Jan 27.

Authors

Bing-Dong Lin¹, Bin Zhou¹, Lei Dong¹, Yan Wu¹, Jian-Min Yue²

Affiliations

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, People's Republic of China.
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, People's Republic of China. jmyue@simm.ac.cn.

Abstract

Three new halimane-type diterpenoids formosins A-C (1-3), and three clerodane-type diterpenoids formosins D-F (4-6), were isolated from the twigs of Excoecaria formosana. Their structures were assigned on the basis of spectroscopic data analysis. Compounds 1 and 4 showed moderate anti-microbial activities against Bacillus subtilis (MIC = 50 and 50 μg/mL, respectively). Compound 6 exhibited moderate anti-microbial activities against two strains of Helicobacter pylori (Hp-SS1 and ATCC 43504) with MIC values of 50 and 50 μg/mL, respectively.

Keywords: Anti-microbial; Clerodane-type; Diterpenoid; Excoecaria formosana; Halimane-type.