Oxidative stress and abdominal aortic aneurysm: potential treatment targets

Theophilus I Emeto; Joseph V Moxon; Minnie Au; Jonathan Golledge

doi:10.1042/CS20150547

Oxidative stress and abdominal aortic aneurysm: potential treatment targets

Clin Sci (Lond). 2016 Mar;130(5):301-15. doi: 10.1042/CS20150547.

Authors

Theophilus I Emeto¹, Joseph V Moxon², Minnie Au³, Jonathan Golledge⁴

Affiliations

¹ Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, James Cook Drive, Douglas, Townsville, QLD 4811, Australia Discipline of Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Studies, James Cook University, Townsville, QLD 4811, Australia.
² Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, James Cook Drive, Douglas, Townsville, QLD 4811, Australia.
³ Discipline of Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Studies, James Cook University, Townsville, QLD 4811, Australia Department of Internal Medicine, The Townsville Hospital, Townsville, QLD 4814, Australia.
⁴ Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, James Cook Drive, Douglas, Townsville, QLD 4811, Australia Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, QLD 4814, Australia jonathan.golledge@jcu.edu.au.

PMID: 26814202
DOI: 10.1042/CS20150547

Abstract

Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key mechanism implicated in AAA pathogenesis is inflammation and the associated production of reactive oxygen species (ROS) and oxidative stress. These have been suggested to promote degradation of the extracellular matrix (ECM) and vascular smooth muscle apoptosis. Experimental and human association studies suggest that ROS can be favourably modified to limit AAA formation and progression. In the present review, we discuss mechanisms potentially linking ROS to AAA pathogenesis and highlight potential treatment strategies targeting ROS. Currently, none of these strategies has been shown to be effective in clinical practice.

Keywords: abdominal aortic aneurysm; animal models; clinical trial; oxidative stress; pharmacotherapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antioxidants / therapeutic use
Aortic Aneurysm, Abdominal / metabolism*
Aortic Aneurysm, Abdominal / prevention & control
Disease Models, Animal
Evidence-Based Medicine / methods
Humans
Molecular Targeted Therapy / methods
Oxidative Stress / drug effects
Oxidative Stress / physiology*
Reactive Oxygen Species / metabolism

Substances

Antioxidants
Reactive Oxygen Species