Adjuvant chemotherapy for resected colorectal cancer metastases: Literature review and meta-analysis

World J Gastroenterol. 2016 Jan 14;22(2):519-33. doi: 10.3748/wjg.v22.i2.519.

Abstract

Surgical resection is the only option of cure for patients with metastatic colorectal cancer (CRC). However, the risk of recurrence within 18 mo after metastasectomy is around 75% and the liver is the most frequent site of relapse. The current international guidelines recommend an adjuvant therapy after surgical resection of CRC metastases despite the lower level of evidence (based on the quality of studies in this setting). However, there is still no standard treatment and the effective role of an adjuvant therapy remains controversial. The aim of this review is to report the state-of-art of systemic chemotherapy and regional chemotherapy with hepatic arterial infusion in the management of patients after resection of metastases from CRC, with a literature review and meta-analysis of the relevant randomized controlled trials.

Keywords: Adjuvant chemotherapy; Adjuvant hepatic artery infusion; Colorectal cancer; Liver metastases; Metastasectomy.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Chemotherapy, Adjuvant
  • Colorectal Neoplasms / mortality
  • Colorectal Neoplasms / pathology*
  • Hepatectomy* / adverse effects
  • Hepatectomy* / mortality
  • Hepatic Artery
  • Humans
  • Infusions, Intra-Arterial
  • Liver Neoplasms / mortality
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / therapy*
  • Metastasectomy / adverse effects
  • Metastasectomy / methods*
  • Metastasectomy / mortality
  • Risk Factors
  • Treatment Outcome

Substances

  • Antineoplastic Agents