The morpholino molecular beacon for specific RNA visualization in vivo

Jianbin Chen; Jikui Wu; Yunhan Hong

doi:10.1039/c5cc07124k

The morpholino molecular beacon for specific RNA visualization in vivo

Chem Commun (Camb). 2016 Feb 21;52(15):3191-4. doi: 10.1039/c5cc07124k.

Authors

Jianbin Chen¹, Jikui Wu², Yunhan Hong¹

Affiliations

¹ Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore. dbshyh@nus.edu.sg.
² Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore. dbshyh@nus.edu.sg and College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.

PMID: 26810703
DOI: 10.1039/c5cc07124k

Abstract

A non-invasive fluorescent probe, morpholino molecular beacon (MO-MB), was designed for RNA visualization in vivo. Featuring negligible toxicity, stability, and high target specificity in living embryos, MO-MB is superior to conventional probes and has the potential for specific RNA visualization in basic biological and clinical research.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fluorescent Dyes / chemistry
Morpholinos / chemistry*
RNA / chemistry*

Substances

Fluorescent Dyes
Morpholinos
RNA