Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells

Matrix Biol. 2016 Apr:51:7-13. doi: 10.1016/j.matbio.2016.01.010. Epub 2016 Jan 22.

Abstract

Fibrosis and scarring are the end stage of many disease processes. In effect, the collagen fibers that initially provide a necessary strength during the repair of injured tissues are frequently synthesized in excessive amounts and become irreversible fibrotic deposits that limit regeneration of the endogenous cells of a tissue. This review will focus on the potential of mesenchymal stem/stromal cells for treatment of fibrotic diseases, with emphasis on the role of TSG-6 as a mediator of anti-inflammatory effects.

Keywords: Mesenchymal stem/stromal cells; Regenerative medicine; TSG-6; Tissue fibrosis.

Publication types

  • Review

MeSH terms

  • Cell Adhesion Molecules / genetics*
  • Cell Adhesion Molecules / therapeutic use
  • Cell- and Tissue-Based Therapy / methods
  • Cicatrix / drug therapy
  • Cicatrix / pathology
  • Collagen / genetics
  • Fibrosis / genetics*
  • Fibrosis / pathology
  • Fibrosis / therapy
  • Humans
  • Inflammation / genetics*
  • Inflammation / pathology
  • Inflammation / therapy
  • Mesenchymal Stem Cell Transplantation*
  • Regeneration / genetics

Substances

  • Cell Adhesion Molecules
  • TNFAIP6 protein, human
  • Collagen