Effect of systemically increasing human full-length Klotho on glucose metabolism in db/db mice

E A Forsberg; H Olauson; T Larsson; S B Catrina

doi:10.1016/j.diabres.2016.01.006

Effect of systemically increasing human full-length Klotho on glucose metabolism in db/db mice

Diabetes Res Clin Pract. 2016 Mar:113:208-10. doi: 10.1016/j.diabres.2016.01.006. Epub 2016 Jan 15.

Authors

E A Forsberg¹, H Olauson², T Larsson², S B Catrina³

Affiliations

¹ The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden. Electronic address: Elisabete.forsberg@ki.se.
² Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
³ The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden; Department of Endocrinology, Diabetes and Metabolism, Karolinska University Hospital, Stockholm, Sweden.

PMID: 26806457
DOI: 10.1016/j.diabres.2016.01.006

Abstract

The metabolic effects of antiaging Klotho were previously investigated in vivo by genetic manipulation. We have here studied the metabolic effect of physiologic levels of circulating full length Klotho in db/db mice. Increasing the full-length human Klotho levels has a positive effect on blood glucose through increasing insulin secretion.

Keywords: Glucose; Insulin and db/db mouse; Klotho; Liver.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Glucose / metabolism
Carbohydrate Metabolism
Diabetes Mellitus, Experimental / blood
Diabetes Mellitus, Experimental / therapy*
Genetic Therapy*
Glucuronidase / genetics*
Humans
Insulin / blood
Klotho Proteins
Liver / metabolism
Male
Mice

Substances

Blood Glucose
Insulin
Glucuronidase
Klotho Proteins