Astroglial Activation and Tau Hyperphosphorylation Precede to Neuron Loss in a Neurodegenerative Mouse Model

CNS Neurosci Ther. 2016 Mar;22(3):244-7. doi: 10.1111/cns.12509. Epub 2016 Jan 25.

Authors

Jin-Xing Hou^{1

2}, Shan-Shan Cheng¹, Lu Chen¹, Qi-Hui Wang¹, Yun Shi¹, Yun Xu³, Zhen-Yu Yin⁴, Gui-Quan Chen¹

Affiliations

¹ State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu Province, China.
² School of Life Sciences, Nanchang University, Nanchang, Jiangxi Province, China.
³ Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu Province, China.
⁴ Department of Geriatric, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu Province, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Amyloid Precursor Protein Secretases / deficiency
Amyloid Precursor Protein Secretases / genetics
Amyloid beta-Protein Precursor / genetics
Amyloid beta-Protein Precursor / metabolism
Animals
Astrocytes / physiology*
Disease Models, Animal
Gene Expression Regulation / genetics*
Glycogen Synthase Kinase 3 / metabolism
Glycogen Synthase Kinase 3 beta
Green Fluorescent Proteins / genetics
Green Fluorescent Proteins / metabolism
Membrane Glycoproteins / deficiency
Membrane Glycoproteins / genetics
Mice
Mice, Transgenic
Neurodegenerative Diseases / genetics
Neurodegenerative Diseases / pathology*
Neurons / pathology*
Phosphorylation / genetics
tau Proteins / metabolism*

Substances

Amyloid beta-Protein Precursor
Membrane Glycoproteins
nicastrin protein
tau Proteins
Green Fluorescent Proteins
Glycogen Synthase Kinase 3 beta
Glycogen Synthase Kinase 3
Amyloid Precursor Protein Secretases