HIV-1 Envelope Under Attack

Wei Wei; Xiao-Fang Yu

doi:10.1016/j.tim.2016.01.004

HIV-1 Envelope Under Attack

Trends Microbiol. 2016 Mar;24(3):164-166. doi: 10.1016/j.tim.2016.01.004. Epub 2016 Jan 20.

Authors

Wei Wei¹, Xiao-Fang Yu²

Affiliations

¹ First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun, Jilin Province, China; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
² First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun, Jilin Province, China; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address: xyu2@jhu.edu.

PMID: 26803378
DOI: 10.1016/j.tim.2016.01.004

Abstract

The human immunodeficiency virus type 1 (HIV-1) envelope (Env) plays a critical role in viral replication and represents a potential target for host antiviral factors. Recent work by Tada and colleagues identifies membrane-associated-RING-CH8 (MARCH8) as a potent anti-HIV factor blocking virion incorporation of Env. Thus, MARCH8 joins a growing list of host factors attacking HIV-1 Env.

Keywords: HIV-1; MARCH8; envelope glycoprotein; virion incorporation.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

HIV Infections / metabolism*
HIV-1 / physiology*
Humans
Membrane Glycoproteins / metabolism*
Ubiquitin-Protein Ligases / metabolism*
Viral Envelope Proteins / metabolism*
Virion / metabolism*
env Gene Products, Human Immunodeficiency Virus / metabolism*

Substances

Membrane Glycoproteins
Viral Envelope Proteins
env Gene Products, Human Immunodeficiency Virus
Ubiquitin-Protein Ligases