Ericoside, a new antibacterial biflavonoid from Erica mannii (Ericaceae)

Gabin Thierry M Bitchagno; Simplice B Tankeo; Apollinaire Tsopmo; James D Simo Mpetga; Alembert T Tchinda; Serge Alain T Fobofou; Antoine Honoré L Nkuete; Ludger A Wessjohann; Victor Kuete; Pierre Tane

doi:10.1016/j.fitote.2015.12.022

Ericoside, a new antibacterial biflavonoid from Erica mannii (Ericaceae)

Fitoterapia. 2016 Mar:109:206-11. doi: 10.1016/j.fitote.2015.12.022. Epub 2016 Jan 21.

Affiliations

¹ Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.
² Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.
³ Food Science and Nutrition, Department of Chemistry, Carleton University, Ottawa, ON, Canada.
⁴ Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 6163, Yaounde, Cameroon.
⁵ Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany.
⁶ Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany.
⁷ Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon. Electronic address: ptane@yahoo.com.

PMID: 26802608
DOI: 10.1016/j.fitote.2015.12.022

Abstract

A new dihydroflavonol-flavonol biflavonoid derivative, named ericoside was isolated from the ethanol extract of the whole plant of Erica mannii along with the known flavonoid, taxifolin 3-O-α-L-rhamnopyranoside; and two readily available sterols (sitosterol, sitosterol 3-O-β-D-glucopyranoside). The isolation was performed using chromatographic methods and the structure of purified molecules were elucidated using spectroscopic techniques (e.g. MS, NMR) and by comparison with literature data. The crude ethanol extract, ericoside, and taxifolin 3-O-α-L-rhamnopyranoside were tested against ten Gram-negative bacteria including multidrug resistant clinical isolates using a broth microdilution method. The crude ethanol extract showed no noteworthy activity. Of the purified compounds, ericoside displayed moderate activity against the resistant Escherichia coli AG100 with a MIC of 64 μg/mL.

Keywords: Antibacterial activity; Biflavonoid; Erica mannii; Ericaceae; Ericoside.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / isolation & purification
Biflavonoids / chemistry*
Biflavonoids / isolation & purification
Cameroon
Ericaceae / chemistry*
Escherichia coli / drug effects
Microbial Sensitivity Tests
Molecular Structure
Plant Extracts / chemistry

Substances

Anti-Bacterial Agents
Biflavonoids
Plant Extracts
ericoside