Abstract
Sulforaphane (SFN), a natural compound occurring in cruciferous vegetables, has been known for years as a chemopreventive agent against many types of cancer. Recently, it has been investigated as an antioxidant and anti-aging agent, and interesting conclusions have been made over the last decade. SFN demonstrated protective effects against ultraviolet (UV)-induced skin damage through several mechanisms of action, for example, decrease of reactive oxygen species production, inhibition of matrix metalloproteinase expression, and induction of phase 2 enzymes. SFN used as a protective agent against UV damage is a whole new matter, and it seems to be a very promising ingredient in upcoming anti-aging drugs and cosmetics.
Keywords:
aging; skin; sulforaphane; ultraviolet.
© 2016 Wiley Periodicals, Inc.
MeSH terms
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Anticarcinogenic Agents / pharmacology*
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Humans
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Isothiocyanates / pharmacology*
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Kelch-Like ECH-Associated Protein 1 / drug effects
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Matrix Metalloproteinase 1 / drug effects
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Matrix Metalloproteinase 3 / drug effects
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NF-E2-Related Factor 2 / drug effects
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NF-kappa B / drug effects
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Radiation-Protective Agents / pharmacology
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Signal Transduction / drug effects*
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Skin / drug effects*
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Skin / radiation effects
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Skin Aging / drug effects*
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Skin Aging / radiation effects
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Sulfoxides
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Transcription Factor AP-1 / drug effects
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Transcription Factor AP-1 / radiation effects
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Ultraviolet Rays / adverse effects
Substances
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Anticarcinogenic Agents
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Isothiocyanates
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KEAP1 protein, human
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Kelch-Like ECH-Associated Protein 1
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NF-E2-Related Factor 2
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NF-kappa B
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NFE2L2 protein, human
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Radiation-Protective Agents
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Sulfoxides
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Transcription Factor AP-1
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Matrix Metalloproteinase 3
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Matrix Metalloproteinase 1
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sulforaphane