A Case Report of a Carbamazepine Overdose With Focus on Pharmacokinetic Aspects

N Mittag; S Meister; A M J Berg; U I Walther

doi:10.1055/s-0035-1569268

A Case Report of a Carbamazepine Overdose With Focus on Pharmacokinetic Aspects

Pharmacopsychiatry. 2016 Mar;49(2):76-8. doi: 10.1055/s-0035-1569268. Epub 2016 Jan 21.

Authors

N Mittag¹, S Meister², A M J Berg¹, U I Walther¹

Affiliations

¹ Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany.
² Department of Neurology, University of Rostock, Rostock, Germany.

PMID: 26797932
DOI: 10.1055/s-0035-1569268

Abstract

In this article a case of carbamazepine overdose is reported. It is common to use immuno-based methods in the field of therapeutic drug monitoring but it might be difficult to adapt such values to toxicological cases. For carbamazepine overdoses it is recommended also to determine the metabolite carbamazepine-10,11-epoxide. Especially for critical conditions a definite substance identification should be performed. In addition, quantifying main metabolites is recommended for an acute clinical toxicological assessment.

Publication types

Case Reports

MeSH terms

Carbamazepine / administration & dosage*
Carbamazepine / analogs & derivatives
Carbamazepine / blood
Carbamazepine / metabolism
Carbamazepine / pharmacokinetics*
Charcoal / therapeutic use
Drug Monitoring / methods*
Drug Overdose / blood*
Drug Overdose / drug therapy
Humans
Male
Middle Aged

Substances

Charcoal
Carbamazepine
carbamazepine epoxide