Nanoparticles: Novel vehicles in treatment of Glioblastoma

Biomed Pharmacother. 2016 Feb:77:98-107. doi: 10.1016/j.biopha.2015.12.014. Epub 2015 Dec 29.

Abstract

Glioblastoma multiform (GBM) is the most common brain tumor. The current GBM treatments comprise of radiation therapy, chemotherapy and surgery. One of the most important problems regarding the treatment of GBM is the presence of blood brain barrier (BBB) which inhibits the efficient drug delivery into central nervous system (CNS). Nanothechnology can help to deliver therapeutic drugs into CNS through crossing the BBB. There are different types of nanoparticles (Nps) which can be manipulated for clinical applications as a treatment for CNS-related disorders. In this review, we will discuss the role of Nps in the treatment of GBM.

Keywords: Drug delivery; Glioblastoma; Nanoparticle; Treatment.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / therapeutic use*
  • Biological Transport
  • Blood-Brain Barrier / metabolism
  • Brain Neoplasms / drug therapy*
  • Drug Delivery Systems
  • Drug Liberation
  • Drug Stability
  • Glioblastoma / drug therapy*
  • Humans
  • Hyperthermia, Induced / methods
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry
  • Nanoparticles / metabolism
  • Particle Size
  • Surface Properties

Substances

  • Antineoplastic Agents