Complete genome sequence of Bifidobacterium animalis subsp. lactis KLDS 2.0603, a probiotic strain with digestive tract resistance and adhesion to the intestinal epithelial cells

J Biotechnol. 2016 Feb 20:220:49-50. doi: 10.1016/j.jbiotec.2016.01.013. Epub 2016 Jan 18.

Abstract

Bifidobacterium animalis subsp. lactis KLDS 2.0603 (abbreviated as KLDS 2.0603) is a probiotic strain isolated from the feces of an adult human. Previous studies showed that KLDS 2.0603 has a high resistance to simulated digestive tract conditions and a high ability to adhere to intestinal epithelial cells (Caco-2). These two characteristics are essential requirements for the selection of probiotic bacteria. To explore the stress resistance mechanism to the digestive tract environment and the adhesive proteins of this strain, in this paper, we reported the complete genome sequence of KLDS 2.0603, which contains 19,469bp and encodes 1614 coding sequences(CDSs), 15 rRNA genes, 52 tRNA genes with 1678 open reading frames.

Keywords: Adhesion; Bifidobacterium animalis subsp. lactis KLDS 2.0603; Digestive tract resistance; Genome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Adhesion
  • Base Composition
  • Base Sequence
  • Bifidobacterium / genetics*
  • Bifidobacterium / metabolism
  • Caco-2 Cells
  • Chromosome Mapping
  • Epithelial Cells / microbiology*
  • Feces / microbiology
  • Gastrointestinal Tract / microbiology*
  • Genome Size
  • Genome, Bacterial*
  • Humans
  • Intestines / microbiology*
  • Molecular Sequence Data
  • Open Reading Frames
  • Probiotics*
  • RNA, Bacterial / genetics

Substances

  • RNA, Bacterial